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However, in the current study, we identify that control of chronic adult filarial worm infection is evident in IL-4Rα-deficient (IL-4Rα-/-) mice, whereby the majority of infections do not achieve patency. An associated residual eosinophilia was apparent in infected IL-4Rα-/ by: 1. Threadlike adult filarial worms reside in lymphatic or subcutaneous tissues. Gravid females produce live offspring (microfilariae) that circulate in blood or migrate through tissues. When ingested by a suitable bloodsucking insect (mosquitoes or flies), microfilariae develop into infective larvae.

Mar 16,  · Even in asymptomatic people, adult filarial worms commonly cause subclinical lymphatic dilatation and dysfunction. Filarial lymphadenopathy is seen commonly in infected children; before puberty, adult worms can be detected by ultrasonography of the inguinal, crural, and axillary lymph nodes and vessels. Mar 16,  · An adult worm lives for about 5–7 years. The adult worms mate and release millions of microscopic worms, called microfilariae, into the blood. People with the worms in their blood can give the infection to others through mosquitoes. Who is at risk for infection?

Jun 22,  · Pathogenic filarial parasites affect the lives of millions of people, especially those living in tropical countries, and may cause significant dermatologic manifestations. The .